major(greater in significance or importance) adjective [UK: ˈmeɪ.dʒə(r)] [US: ˈmeɪ.dʒər]
meaningful(having meaning, significant) adjective [UK: ˈmiː.nɪŋ.fəl] [US: ˈmiː.nɪŋ.fəl]Remember that life's simple joys are often the most meaningful and can bring lasting happiness. = Ricorda che le gioie semplici della vita sono spesso le più significative e possono dare una felicità duratura.
notable(worthy of notice; remarkable) adjective [UK: ˈnəʊ.təb.l̩] [US: ˈnoʊ.təb.l̩]
predominant(significant or important; dominant) adjective [UK: prɪ.ˈdɒ.mɪ.nənt] [US: prə.ˈdɑː.mə.nənt]
sensical(that makes sense, see also: rational; sensible) adjective
significant(signifying something; carrying meaning) adjective [UK: sɪɡ.ˈnɪ.fɪkənt] [US: sɪg.ˈnɪ.fɪkənt]Every word is significant. = Ogni parola è significativa.